Effect of High-intensity Interval Training on Endothelial Function in Type 2 Diabetic Females

Background: Flow-mediated dilation (FMD) is a noninvasive approach to examine endothelial function. Objectives: The purpose of this study was investigate the effect 12 weeks high-intensity interval training (HIIT) on FMD and circulating levels adropin nitric oxide (NO) in females with type 2 diabetes. Methods: Thirty diabetes were randomly assigned into two equal groups HIIT control. exercise program consisted three sessions week for weeks. Each session included 4 × 4-minute running intervals at 85 - 95% maximal heart rate (HRmax) 3-minute active recoveries 50 60% HRmax. Circulating adropin, NO, glucose, HbA1c, insulin, HOMA-IR, as well lipid profile, body composition parameters measured before after intervention. Results: A significant increase FMD% observed intervention group (P = 0.001). In addition, circulation NO enhanced result 0.012 P < 0.001, respectively). There also positive effects profile (except HDL), FBS, HbA1c; insulin resistance variables. no changes control except an total cholesterol 0.01). Conclusions: results showed that could improve function, glucose-related indices, variables